The Gam protein of bacteriophage Mu is an orthologue of eukaryotic Ku.

  title={The Gam protein of bacteriophage Mu is an orthologue of eukaryotic Ku.},
  author={Fabrizio d'Adda di Fagagna and Geoffrey R. Weller and Aidan J. Doherty and Stephen P. Jackson},
  journal={EMBO reports},
  volume={4 1},
Mu bacteriophage inserts its DNA into the genome of host bacteria and is used as a model for DNA transposition events in other systems. The eukaryotic Ku protein has key roles in DNA repair and in certain transposition events. Here we show that the Gam protein of phage Mu is conserved in bacteria, has sequence homology with both subunits of Ku, and has the potential to adopt a similar architecture to the core DNA-binding region of Ku. Through biochemical studies, we demonstrate that Gam and the… CONTINUE READING
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