The Gag Cleavage Product, p12, is a Functional Constituent of the Murine Leukemia Virus Pre-Integration Complex

@inproceedings{PrizanRavid2010TheGC,
  title={The Gag Cleavage Product, p12, is a Functional Constituent of the Murine Leukemia Virus Pre-Integration Complex},
  author={Adi Prizan-Ravid and Efrat Elis and Nihay Laham-Karam and Sara M. Selig and Marcelo Ehrlich and Eran Bacharach},
  booktitle={PLoS pathogens},
  year={2010}
}
The p12 protein is a cleavage product of the Gag precursor of the murine leukemia virus (MLV). Specific mutations in p12 have been described that affect early stages of infection, rendering the virus replication-defective. Such mutants showed normal generation of genomic DNA but no formation of circular forms, which are markers of nuclear entry by the viral DNA. This suggested that p12 may function in early stages of infection but the precise mechanism of p12 action is not known. To address the… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 60 references

Sequence and spacing requirements of a retrovirus integration site.

Journal of molecular biology • 1988
View 4 Excerpts
Highly Influenced

Functional characterization of a portion of the Moloney murine leukemia virus gag gene by genetic footprinting.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 4 Excerpts
Highly Influenced

Assays for retroviral reverse transcriptase.

Methods in enzymology • 1995
View 3 Excerpts
Highly Influenced

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