The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs.

@article{Brencic2009TheGS,
  title={The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs.},
  author={Anja Brencic and Kirsty A McFarland and Heather R McManus and Sandra Castang and Ilaria Mogno and Simon L. Dove and Stephen Lory},
  journal={Molecular microbiology},
  year={2009},
  volume={73 3},
  pages={434-45}
}
We report here the results of an analysis of the regulatory range of the GacS/GacA two-component system in Pseudomonas aeruginosa. Using microarrays, we identified a large number of genes that are regulated by the system, and detected a near complete overlap of these genes with those regulated by two small RNAs (sRNAs), RsmY and RsmZ, suggesting that the expression of all GacA-regulated genes is RsmY/Z-dependent. Using genome-wide DNA-protein interaction analyses, we identified only two genomic… CONTINUE READING
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