The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor.

@article{Ingham1998TheGP,
  title={The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor.},
  author={Robert J. Ingham and Marina Holgado-Madruga and C S Siu and Albert J. Wong and Michael R Gold},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 46},
  pages={30630-7}
}
Gab1 is a member of the docking/scaffolding protein family which includes IRS-1, IRS-2, c-Cbl, p130(cas), and p62(dok). These proteins contain a variety of protein-protein interaction motifs including multiple tyrosine residues that when phosphorylated can act as binding sites for Src homology 2 (SH2) domain-containing signaling proteins. We show in the… CONTINUE READING

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