The GTPase RalA Regulates Different Steps of the Secretory Process in Pancreatic β-Cells

@inproceedings{Ljubicic2009TheGR,
  title={The GTPase RalA Regulates Different Steps of the Secretory Process in Pancreatic β-Cells},
  author={Sanda Ljubicic and Paola Bezzi and Nicolas Vitale and Romano Regazzi},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND RalA and RalB are multifuntional GTPases involved in a variety of cellular processes including proliferation, oncogenic transformation and membrane trafficking. Here we investigated the mechanisms leading to activation of Ral proteins in pancreatic beta-cells and analyzed the impact on different steps of the insulin-secretory process. METHODOLOGY/PRINCIPAL FINDINGS We found that RalA is the predominant isoform expressed in pancreatic islets and insulin-secreting cell lines… CONTINUE READING

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