The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport

@inproceedings{Huet2014TheGI,
  title={The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport},
  author={Diego Huet and Thierry Blisnick and Sylvie Perrot and Philippe Bastin},
  booktitle={eLife},
  year={2014}
}
The construction of cilia and flagella depends on intraflagellar transport (IFT), the bidirectional movement of two protein complexes (IFT-A and IFT-B) driven by specific kinesin and dynein motors. IFT-B and kinesin are associated to anterograde transport whereas IFT-A and dynein participate to retrograde transport. Surprisingly, the small GTPase IFT27, a member of the IFT-B complex, turns out to be essential for retrograde cargo transport in Trypanosoma brucei. We reveal that this is due to… CONTINUE READING

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