The GTP binding proteins Gem and Rad are negative regulators of the Rho–Rho kinase pathway

@article{Ward2002TheGB,
  title={The GTP binding proteins Gem and Rad are negative regulators of the Rho–Rho kinase pathway},
  author={Yvona Ward and Seow-Fong Yap and Veeraswamy Ravichandran and Fumio Matsumura and Masaaki Ito and Beth Spinelli and Kathleen Kelly},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={157},
  pages={291 - 302}
}
The cytoskeletal changes that alter cellular morphogenesis and motility depend upon a complex interplay among molecules that regulate actin, myosin, and other cytoskeletal components. The Rho family of GTP binding proteins are important upstream mediators of cytoskeletal organization. Gem and Rad are members of another family of small GTP binding proteins (the Rad, Gem, and Kir family) for which biochemical functions have been mostly unknown. Here we show that Gem and Rad interface with the Rho… CONTINUE READING

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