The GTP binding protein Obg homolog ObgE is involved in ribosome maturation.

  title={The GTP binding protein Obg homolog ObgE is involved in ribosome maturation.},
  author={Aya Sato and Gengo Kobayashi and Hiroshi Hayashi and Hideji Yoshida and Akira Wada and Maki Maeda and Sota Hiraga and Kunio Takeyasu and Chieko Wada},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  volume={10 5},
Obg proteins belong to a subfamily of GTP binding proteins, which are highly conserved from bacteria to human. Mutations of obgE genes cause pleiotropic defects in various species but the function remained unclear. Here we examine the function of ObgE, the Obg homolog in Escherichia coli. The growth rate correlates with the amount of ObgE in cells. Co-fractionation experiments further suggest that ObgE binds to 30S and 50S ribosomal subunits, but not to 70S ribosome. Pull-down assays suggest… CONTINUE READING
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