The GTP binding motif: variations on a theme.

  title={The GTP binding motif: variations on a theme.},
  author={Morten Kjeldgaard and Jens Nyborg and Brian F. C. Clark},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={10 12},
GTP binding proteins (G-proteins) have wide-ranging functions in biology, being involved in cell proliferation, signal transduction, protein synthesis, and protein targeting. Common to their functioning is that they are active in the GTP-bound form and inactive in the GDP-bound form. The protein synthesis elongation factor EF-Tu was the first G-protein whose nucleotide binding domain was solved structurally by X-ray crystallography to yield a structural definition of the GDP-bound form, but a… CONTINUE READING


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