The GRIMs: a new interface between cell death regulation and interferon/retinoid induced growth suppression.

@article{Kalvakolanu2004TheGA,
  title={The GRIMs: a new interface between cell death regulation and interferon/retinoid induced growth suppression.},
  author={Dhananjaya V. Kalvakolanu},
  journal={Cytokine & growth factor reviews},
  year={2004},
  volume={15 2-3},
  pages={169-94}
}
Cytokines and vitamins play a central role in controlling neoplastic cell growth. The interferon (IFN) family of cytokines regulates antiviral, anti-tumor, antimicrobial, differentiation, and immune responses in mammals. Significant advances have been made with respect to IFN-induced signal transduction pathways and antiviral responses. However, the IFN-induced anti-tumor actions are poorly defined. Although IFNs themselves inhibit tumor growth, combination of IFNs with retinoids (a class of… CONTINUE READING

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