The GPR55 ligand L‐α‐lysophosphatidylinositol promotes RhoA‐dependent Ca2+ signaling and NFAT activation

@article{Henstidge2009TheGL,
  title={The GPR55 ligand L‐α‐lysophosphatidylinositol promotes RhoA‐dependent Ca2+ signaling and NFAT activation},
  author={Christopher M. Henstidge and Nariman A. B. Balenga and Lesley A. Ford and Ruth A. Ross and M. Waldhoer and Andrew J. Irving},
  journal={The FASEB Journal},
  year={2009},
  volume={23},
  pages={183 - 193}
}
  • Christopher M. Henstidge, Nariman A. B. Balenga, +3 authors Andrew J. Irving
  • Published 2009
  • Chemistry, Medicine, Biology
  • The FASEB Journal
  • The endogenous phospholipid l‐α‐lyso‐phosphatidylinositol (LPI) was recently identified as a novel ligand for the orphan G protein‐coupled receptor 55 (GPR55). In this study we define the downstream signaling pathways activated by LPI in a human embryonic kidney (HEK) 293 cell line engineered to stably express recombinant human GPR55. We find that treatment with LPI induces marked GPR55 internalization and stimulates a sustained, oscillatory Ca2+ release pathway, which is dependent on Gα13 and… CONTINUE READING
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