The GPR55 ligand L‐α‐lysophosphatidylinositol promotes RhoA‐dependent Ca2+ signaling and NFAT activation

  title={The GPR55 ligand L‐α‐lysophosphatidylinositol promotes RhoA‐dependent Ca2+ signaling and NFAT activation},
  author={Christopher M. Henstidge and Nariman A. B. Balenga and Lesley A. Ford and Ruth A. Ross and M. Waldhoer and Andrew J. Irving},
  journal={The FASEB Journal},
  pages={183 - 193}
  • Christopher M. Henstidge, Nariman A. B. Balenga, +3 authors Andrew J. Irving
  • Published 2009
  • Chemistry, Medicine, Biology
  • The FASEB Journal
  • The endogenous phospholipid l‐α‐lyso‐phosphatidylinositol (LPI) was recently identified as a novel ligand for the orphan G protein‐coupled receptor 55 (GPR55). In this study we define the downstream signaling pathways activated by LPI in a human embryonic kidney (HEK) 293 cell line engineered to stably express recombinant human GPR55. We find that treatment with LPI induces marked GPR55 internalization and stimulates a sustained, oscillatory Ca2+ release pathway, which is dependent on Gα13 and… CONTINUE READING
    236 Citations
    Modulation of l-α-lysophosphatidylinositol/GPR55 MAP kinase signalling by CB2 receptor agonists: identifying novel GPR55 inhibitors
    • 3
    Modulation of l-α-Lysophosphatidylinositol/GPR55 Mitogen-activated Protein Kinase (MAPK) Signaling by Cannabinoids*
    • 95
    • PDF
    The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation
    • 175
    • Highly Influenced
    • PDF
    A Selective Antagonist Reveals a Potential Role of G Protein–Coupled Receptor 55 in Platelet and Endothelial Cell Function
    • 57
    GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils
    • 58
    • PDF


    Identification of GPR55 as a lysophosphatidylinositol receptor.
    • 340
    • Highly Influential
    Ligand‐induced down‐regulation of the cannabinoid 1 receptor is mediated by the G‐protein‐coupled receptor‐associated sorting protein GASP1
    • L. Martini, M. Waldhoer, +5 authors J. Whistler
    • Biology, Medicine
    • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    • 2007
    • 128
    GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current
    • 493
    • Highly Influential
    • PDF
    Modulation of NFAT‐dependent gene expression by the RhoA signaling pathway in T cells
    • 19
    Novel cannabinoid receptors
    • A. J. Brown
    • Biology, Medicine
    • British journal of pharmacology
    • 2007
    • 348
    Characterization of proteinase-activated receptor 2 signalling and expression in rat hippocampal neurons and astrocytes
    • 41