The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH.

@article{Saxena2012TheGO,
  title={The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH.},
  author={Himansh Saxena and Deepak A. Deshpande and Brian C Tiegs and Hong Yan and Richard J. Battafarano and Whitney M. Burrows and Gautam Damera and Reynold A Panettieri and Thomas D Dubose and Steven S. An and Raymond B. Penn},
  journal={British journal of pharmacology},
  year={2012},
  volume={166 3},
  pages={981-90}
}
BACKGROUND AND PURPOSE Previous studies have linked a reduction in pH in airway, caused by either environmental factors, microaspiration of gastric acid or inflammation, with airway smooth muscle (ASM) contraction and increased airway resistance. Neural mechanisms have been shown to mediate airway contraction in response to reductions in airway pH to < 6.5; whether reduced extracellular pH (pHo) has direct effects on ASM is unknown. EXPERIMENTAL APPROACH Intracellular signalling events… CONTINUE READING
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