The GM-CSF receptor family: mechanism of activation and implications for disease.

Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pluripotent cytokine produced by many cells in the body, which regulates normal and malignant hemopoiesis as well as innate and adaptive immunity. GM-CSF assembles and activates its heterodimeric receptor complex on the surface of myeloid cells, initiating multiple signaling pathways that… (More)
DOI: 10.3109/08977194.2011.649919

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Cite this paper

@article{Hercus2012TheGR, title={The GM-CSF receptor family: mechanism of activation and implications for disease.}, author={Timothy R. Hercus and Sophie E Broughton and Paul G Ekert and Hayley S. Ramshaw and Michelle Perugini and Michele A. Grimbaldeston and Joanna M Woodcock and Daniel T Thomas and Stuart M Pitson and Timothy R. Hughes and Richard J. D'Andrea and Michael W Parker and Angel F Lopez}, journal={Growth factors}, year={2012}, volume={30 2}, pages={63-75} }