The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism

@inproceedings{Andreozzi2016TheGR,
  title={The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism},
  author={Francesco Andreozzi and Gregory Alexander Raciti and Cecilia Nigro and Gaia Chiara Mannino and Teresa Procopio and Alberto M. Davalli and Francesco B{\'e}guinot and Giorgio Sesti and Claudia Miele and Franco Folli},
  booktitle={Journal of Translational Medicine},
  year={2016}
}
Aims/hypothesisPotentiation of glucose-induced insulin secretion is the main mechanism of exenatide (EXE) antidiabetic action, however, increased glucose utilization by peripheral tissues has been also reported. We here studied the effect of EXE on glucose uptake by skeletal muscle cells.Methods2-deoxy-glucose (2DG) uptake and intracellular signal pathways were measured in rat L6 skeletal muscle myotubes exposed to 100 nmol/l EXE for up to 48 h. Mechanisms of EXE action were explored by… CONTINUE READING
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  • 2016

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