The GK rat beta-cell: a prototype for the diseased human beta-cell in type 2 diabetes?


Increasing evidence indicates that decreased functional beta-cell mass is the hallmark of type 2 diabetes (T2D) mellitus. Nowadays, the debate focuses on the possible mechanisms responsible for abnormal islet microenvironment, decreased beta-cell number, impaired beta-cell function, and their multifactorial aetiologies. This review is aimed to illustrate to… (More)
DOI: 10.1016/j.mce.2008.06.013