The GINS complex: structure and function.

Abstract

Eukaryotic chromosomal DNA replication is controlled by a highly ordered series of steps involving multiple proteins at replication origins. The eukaryotic GINS complex is essential for the establishment of DNA replication forks and replisome progression. GINS is one of the core components of the eukaryotic replicative helicase, the CMG (Cdc45-MCM-GINS) complex, which unwinds duplex DNA ahead of the moving replication fork. Eukaryotic GINS also links with other key proteins at the fork to maintain an active replisome progression complex. Archaeal GINS homologues play a central role in chromosome replication by associating with other replisome components. This chapter focuses on the molecular events related with DNA replication initiation, and summarizes our current understanding of the function, structure and evolution of the GINS complex in eukaryotes and archaea.

DOI: 10.1007/978-94-007-4572-8_8
0500100020132014201520162017
Citations per Year

1,222 Citations

Semantic Scholar estimates that this publication has 1,222 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Kamada2012TheGC, title={The GINS complex: structure and function.}, author={Katsuhiko Kamada}, journal={Sub-cellular biochemistry}, year={2012}, volume={62}, pages={135-56} }