The GINS complex from the thermophilic archaeon, Thermoplasma acidophilum may function as a homotetramer in DNA replication

@article{Ogino2011TheGC,
  title={The GINS complex from the thermophilic archaeon, Thermoplasma acidophilum may function as a homotetramer in DNA replication},
  author={Hiromi Ogino and Sonoko Ishino and Kouta Mayanagi and Gyri Teien Haugland and Nils-K{\aa}re Birkeland and Akihiko Yamagishi and Yoshizumi Ishino},
  journal={Extremophiles},
  year={2011},
  volume={15},
  pages={529-539}
}
The eukaryotic GINS heterotetramer, consisting of Sld5, Psf1, Psf2, and Psf3, participates in “CMG complex” formation with mini-chromosome maintenance (MCM) and Cdc45 as a key component of a replicative helicase. There are only two homologs of the GINS proteins in Archaea, and these proteins, Gins51 and Gins23, form a heterotetrameric GINS with a 2:2 molar ratio. The Pyrococcus furiosus GINS stimulates the ATPase and helicase activities of its cognate MCM, whereas the Sulfolobus solfataricus… CONTINUE READING
BETA
1
Twitter Mention

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 53 REFERENCES

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

DNA replication initiation: mechanisms and regulation in bacteria

  • Nature Reviews Microbiology
  • 2007
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL