The GHS-R Blocker D-[Lys3] GHRP-6 Serves as CCR5 Chemokine Receptor Antagonist

  title={The GHS-R Blocker D-[Lys3] GHRP-6 Serves as CCR5 Chemokine Receptor Antagonist},
  author={Kalpesh Patel and V. Dixit and J. Lee and J. W. Kim and E. M. Schaffer and Dzung Nguyen and D. Taub},
  journal={International Journal of Medical Sciences},
  pages={51 - 58}
  • Kalpesh Patel, V. Dixit, +4 authors D. Taub
  • Published 2012
  • Biology, Medicine
  • International Journal of Medical Sciences
  • [D-Lys3]-Growth Hormone Releasing Peptide-6 (DLS) is widely utilized in vivo and in vitro as a selective ghrelin receptor (GHS-R) antagonist. This antagonist is one of the most common antagonists utilized in vivo to block GHS-R function and activity. Here, we found that DLS also has the ability to modestly block chemokine function and ligand binding to the chemokine receptor CCR5. The DLS effects on RANTES binding and Erk signaling as well as calcium mobilization appears to be much stronger… CONTINUE READING
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