The GDNF family members neurturin, artemin and persephin promote the morphological differentiation of cultured ventral mesencephalic dopaminergic neurons

@article{Zihlmann2005TheGF,
  title={The GDNF family members neurturin, artemin and persephin promote the morphological differentiation of cultured ventral mesencephalic dopaminergic neurons},
  author={Karin B. Zihlmann and Ang{\'e}lique D Ducray and Beno{\^i}t Schaller and Alexander W. Huber and Sandra H. Krebs and Robert Hans Andres and Rolf W. Seiler and Morten Meyer and Hans Rudolf Widmer},
  journal={Brain Research Bulletin},
  year={2005},
  volume={68},
  pages={42-53}
}
Transforming Growth Factor β Cooperates with Persephin for Dopaminergic Phenotype Induction
TLDR
The combination of TGF‐β with PSPN is a potent inductive cocktail for the generation of dopaminergic neurons that should be considered in tissue engineering and cell replacement therapies for Parkinson's disease, and results indicate that phenotype induction and survival of fully differentiated neurons are accomplished through distinct pathways and individual factor requirement.
Specificity in the crosstalk of TGFβ/GDNF family members is determined by distinct GFR alpha receptors
TLDR
A model taking into account data from GFRα1 crystallization and ontogenetic development of the CG is proposed that may explain the differences in TGFβ‐dependence of GDNF and NRTN.
The role of glial cell line‐derived neurotrophic factor family member artemin in neurological disorders and cancers
TLDR
The role of ARTN in spinal cord injury, neuropathic pain and other neurological disorders is discussed, and its role in non‐neuron tissues, such as the formation of Peyer's patch‐like structures in the lymphoid tissue of the gut is explored.
Neurturin Effects on Nigrostriatal Dopamine Release and Content: Comparison with GDNF
TLDR
NTN, like GDNF, can augment striatal DA release, and the magnitude of the NTN effects are similar to those of GDNF.
Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP+ in dissociated cultures from rat mesencephalon.
TLDR
Findings that CDNF and N4 may be of therapeutic value for treatment of PD are supported, but suggest that they may need to be administered together.
The Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural Cells
TLDR
The understanding of the complete range of properties of this trophic molecule will allow us to investigate its broad mechanisms of action to accelerate and/or improve therapies for the aforementioned pathological conditions.
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The pattern of GF factor and receptor expression in the adult brain suggests a role for these factors in maintaining neuronal circuits in the mature CNS.
Novel functions and signalling pathways for GDNF
TLDR
Glial-cell-line-derived neurotrophic factor (GDNF) was originally identified as a survival factor for midbrain dopaminergic neurons but has further critical roles outside the nervous system in the regulation of kidney morphogenesis and spermatogenesis.
Differential Effects of Glial Cell Line‐Derived Neurotrophic Factor and Neurturin on Developing and Adult Substantia Nigra Dopaminergic Neurons
TLDR
Neurturin was found to be as potent as GDNF at preventing the death of nigral dopaminergic neurons, but only GDNF induced tyrosine hydroxylase staining, sprouting, or hypertrophy of dopamine neurons in vivo.
In Vivo Protection of Nigral Dopamine Neurons by Lentiviral Gene Transfer of the Novel GDNF-Family Member Neublastin/Artemin
TLDR
It is concluded that NBN/ART, similarly to GDNF, is a potent neuroprotective factor for the nigrostriatal DA neurons in vivo.
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TLDR
It is shown that GDNF binds to, and induces tyrosine phosphorylation of, the product of the c-ret proto-oncogene, an orphan receptor tyrosin kinase, in a GDNF responsive motor-neuron cell line, which encodes a functional receptor for GDNF that may mediate its neurotrophic effects on motor and dopaminergic neurons.
Neurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic Neurons
TLDR
It is suggested that neurturin (NTN), a homolog of GDNF, is expressed in the nigrostriatal system, and that NTN exerts potent effects on survival and function of midbrain DA neurons and point to the possibility that GDNF and NTN may exert redundant trophic influences on nigral DA neurons acting via a receptor complex that includes GFRα1.
Glial Cell Line-Derived Neurotrophic Factor Stimulates the Morphological Differentiation of Cultured Ventral Mesencephalic Calbindin- and Calretinin-Expressing Neurons
TLDR
Findings recognize GDNF as a neurotrophic factor that stimulates the morphological differentiation of ventral mesencephalic CB-ir and CR-ir neurons.
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