The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

@article{Chandra2011TheGS,
  title={The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins},
  author={Anchal Chandra and Hern{\'a}n E. Grecco and Venkat Pisupati and David Perera and Liam Cassidy and Ferdinandos Skoulidis and Shehab A. Ismail and Christian Hedberg and Michael F Hanzal-Bayer and Ashok R. Venkitaraman and Alfred Wittinghofer and Philippe I H Bastiaens},
  journal={Nature Cell Biology},
  year={2011},
  volume={14},
  pages={148-158}
}
We identify a role for the GDI-like solubilizing factor (GSF) PDEδ in modulating signalling through Ras family G proteins by sustaining their dynamic distribution in cellular membranes. We show that the GDI-like pocket of PDEδ binds and solubilizes farnesylated Ras proteins, thereby enhancing their diffusion in the cytoplasm. This mechanism allows more effective trapping of depalmitoylated Ras proteins at the Golgi and polycationic Ras proteins at the plasma membrane to counter the entropic… CONTINUE READING