The GCR1 requirement for yeast glycolytic gene expression is suppressed by dominant mutations in the SGC1 gene, which encodes a novel basic-helix-loop-helix protein.

@article{Nishi1995TheGR,
  title={The GCR1 requirement for yeast glycolytic gene expression is suppressed by dominant mutations in the SGC1 gene, which encodes a novel basic-helix-loop-helix protein.},
  author={Kayoko Nishi and Chul Soo Park and Amy E. Pepper and G H Eichinger and Michael A. Innis and Michael J Holland},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 5},
  pages={2646-53}
}
The GCR1 gene product is required for maximal transcription of yeast glycolytic genes and for growth of yeast strains in media containing glucose as a carbon source. Dominant mutations in two genes, SGC1 and SGC2, as well as recessive mutations in the SGC5 gene were identified as suppressors of the growth and transcriptional defects caused by a gcr1 null mutation. The wild-type and mutant alleles of SGC1 were cloned and sequenced. The predicted amino acid sequence of the SGC1 gene product… CONTINUE READING
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