The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores.

@article{Maurin2005TheGK,
  title={The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores.},
  author={Anne-Catherine Maurin and C{\'e}line Jousse and Julien Av{\'e}rous and Laurent Parry and Alain Bruhat and Yoan Ch{\'e}rasse and Huiqing Zeng and Yuhong Zhang and Heather P Harding and David Ron and Pierre Fafournoux},
  journal={Cell metabolism},
  year={2005},
  volume={1 4},
  pages={273-7}
}
To insure an adequate supply of nutrients, omnivores choose among available food sources. This process is exemplified by the well-characterized innate aversion of omnivores to otherwise nutritious foods of imbalanced amino acid content. We report that brain-specific inactivation of GCN2, a ubiquitously expressed protein kinase that phosphorylates translation initiation factor 2 alpha (eIF2alpha) in response to intracellular amino acid deficiency, impairs this aversive response. GCN2… CONTINUE READING

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