The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control

@inproceedings{Pereira2019TheGI,
  title={The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control},
  author={C. M. Caetano Pereira and Renato Filev and Francisco Paulino Dubiela and Bruna Brand{\~a}o and Claudio Marcos Queiroz and Raissa Guimar{\~a}es Ludwig and D{\'e}bora Cristina Hip{\'o}lide and Beatriz Monteiro Longo and Luiz E Mello and Marcelo A. Mori and Beatriz A. Castilho},
  booktitle={PloS one},
  year={2019}
}
IMPACT, a highly conserved protein, is an inhibitor of the eIF2α kinase GCN2. In mammals, it is preferentially expressed in neurons. Knock-down of IMPACT expression in neuronal cells increases basal GCN2 activation and eIF2α phosphorylation and decreases translation initiation. In the mouse brain, IMPACT is particularly abundant in the hypothalamus. Here we describe that the lack of IMPACT in mice affects hypothalamic functions. Impact-/- mice (Imp-KO) are viable and have no apparent major… CONTINUE READING
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