The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes

@article{Spars2007TheGR,
  title={The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes},
  author={Thomas Hempel Spars\o and Gitte Andersen and Trine Nielsen and K. S. Burgdorf and Anette Prior Gjesing and Arne L Nielsen and Anders Albrechtsen and Signe S. Rasmussen and Torben J\orgensen and Knut Borch-Johnsen and Annelli Sandb{\ae}k and Ted Lauritzen and Sten Madsbad and Torben Hansen and Oluf Pedersen},
  journal={Diabetologia},
  year={2007},
  volume={51},
  pages={383-383}
}
Unfortunately, there was a mistake in the last sentence of the Abstract. The Conclusions/Interpretation should have read as follows: ‘The GCKR rs780094 polymorphism, or another variant with which it is in tight linkage disequilibrium, is likely to increase glucokinase regulatory protein activity to induce improved glycaemic regulation at the expense of hypertriacylglycerolaemia as reflected in the present study of 16,853 Danes. We also suggest an additive effect of GCK and GCKR risk alleles on… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 84 extracted citations

Similar Papers

Loading similar papers…