The GATC-binding protein SeqA is required for bile resistance and virulence in Salmonella enterica serovar typhimurium.

@article{Prieto2007TheGP,
  title={The GATC-binding protein SeqA is required for bile resistance and virulence in Salmonella enterica serovar typhimurium.},
  author={Ana Isabel Prieto and Marcello Jakomin and Ignacio Segura and M Graciela Pucciarelli and Francisco Ramos-Morales and Francisco Garc{\'i}a-Del Portillo and Josep M Casades{\'u}s},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 23},
  pages={8496-502}
}
Disruption of the seqA gene of Salmonella enterica serovar Typhimurium causes defects similar to those described in E. coli: filament formation, aberrant nucleoid segregation, induction of the SOS response, envelope instability, and increased sensitivity to membrane-damaging agents. Differences between SeqA(-) mutants of E. coli and S. enterica, however, are found. SeqA(-) mutants of S. enterica form normal colonies and do not exhibit alterations in phage plaquing morphology. Lack of SeqA… CONTINUE READING

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