The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21.

@article{Martin1990TheGD,
  title={The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21.},
  author={George A. Martin and David Viskochil and Gideon Bollag and Peter C. McCabe and W J Crosier and Heinz Haubruck and Leah Conroy and Robin Clark and P. O'Connell and Richard M. Cawthon},
  journal={Cell},
  year={1990},
  volume={63 4},
  pages={843-9}
}
The neurofibromatosis type 1 (NF1) protein contains a region of significant sequence similarity to ras p21 GTPase-activating protein (GAP) and the yeast IRA1 gene product. A fragment of NF1 cDNA encoding the GAP-related domain (NF1 GRD) was expressed, immunoaffinity purified, and assayed for effects on N-ras p21 GTPase activity. The GTPase of wild-type ras p21 was stimulated by NF1 GRD, but oncogenic mutants of ras p21 (Asp-12 and Val-12) were unaffected, and the GTPase of an effector mutant… CONTINUE READING

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