The GABAergic nervous system of Caenorhabditis elegans

  title={The GABAergic nervous system of Caenorhabditis elegans},
  author={Steven L. Mclntire and Erik Jorgensen and Joshua Kaplan and H Robert Horvitz},
γ-AMINOBUTYRIC acid (GABA) is the most abundant inhibitory neurotransmitter in vertebrates and invertebrates1. GABA receptors are the target of anxiolytic, antiepileptic and antispasmodic drugs2, as well as of commonly used insecticides3. How does a specific neurotransmitter such as GABA control animal behaviour? To answer this question, we identified all neurons that react with antisera raised against the neurotransmitter GABA in the nervous system of the nematode Caenorhabditis elegans. We… CONTINUE READING
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