The GABAB receptor is a novel drug target for pancreatic cancer

Abstract

Background—Pancreatic ductal adenocarcinoma (PDAC) a leading cause of cancer death. Smoking, diabetes and pancreatitis are risk factors. We have shown that the growth of PDAC and pancreatic duct epithelial cells is regulated by beta-adrenoreceptors (β-ARs). The activity of βARs in the central nervous system is counteracted by γ-aminobutyric acid (GABA) via… (More)

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