The GABAB receptor antagonist, CGP-35348, inhibits paired-pulse disinhibition in the rat dentate gyrus in vivo.

@article{Brucato1992TheGR,
  title={The GABAB receptor antagonist, CGP-35348, inhibits paired-pulse disinhibition in the rat dentate gyrus in vivo.},
  author={Frederic H Brucato and Richard A. Morrisett and Wilkie A. Wilson and H Scott Swartzwelder},
  journal={Brain research},
  year={1992},
  volume={588 1},
  pages={150-3}
}
Extracellular field potentials were recorded from the dentate gyrus of adult rats during electrical stimulation of the angular bundle in vivo. Paired pulses produced inhibition of the second population spike (PS2) at 25 ms, and potentiation at inter-stimulus intervals from 50 to 200 ms. The GABAB receptor antagonist, CGP 35348, reduced the amplitude of PS2 at each of these inter-stimulus intervals while producing no effect on the first population spike of the pair (PS1). Under control… CONTINUE READING

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