The GABAA receptor complex in relation to epilepsy. Reversal of [3H]TBOB inhibition: a prediction of proconvulsive properties?

@article{Rijn1992TheGR,
  title={The GABAA receptor complex in relation to epilepsy. Reversal of [3H]TBOB inhibition: a prediction of proconvulsive properties?},
  author={Clementina M. van Rijn and Elly Willems-van Bree and Ris Dirksen and J. F. Rodrigues Miranda},
  journal={Epilepsy Research},
  year={1992},
  volume={12},
  pages={163-170}
}
  • Clementina M. van Rijn, Elly Willems-van Bree, +1 author J. F. Rodrigues Miranda
  • Published 1992
  • Medicine, Chemistry
  • Epilepsy Research
  • [3H]-t-Butylbicycloorthobenzoate ([3H]TBOB), a convulsant, is known to label a binding site on the GABAA receptor complex. Bicuculline methochloride (bicuculline MCl), folic acid, pentazocine, naloxone, ethyl-beta-carboline-3-carboxylate (beta CCE) and Ro 5-4864 have (pro)convulsive properties in vivo. In the present study, we determined the extent to which these compounds modify the binding of [3H]TBOB in the presence of IC50 amounts of GABA (5 microM) or diazepam (50 microM). We found that… CONTINUE READING