The GABA excitatory/inhibitory developmental sequence: A personal journey

@article{BenAri2014TheGE,
  title={The GABA excitatory/inhibitory developmental sequence: A personal journey},
  author={Yehezkel Ben-Ari},
  journal={Neuroscience},
  year={2014},
  volume={279},
  pages={187-219}
}
The developing brain is talkative but its language is not that of the adult. Most if not all voltage and transmitter-gated ionic currents follow a developmental sequence and network-driven patterns differ in immature and adult brains. This is best illustrated in studies engaged almost three decades ago in which we observed elevated intracellular chloride (Cl(-))i levels and excitatory GABA early during development and a perinatal excitatory/inhibitory shift. This sequence is observed in a wide… CONTINUE READING
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Development of the chloride homeostasis in the auditory brainstem

  • I Milenković, R Rübsamen
  • Physiol Res 60(Suppl
  • 2011
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