The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development.

@article{Ritter2004TheGR,
  title={The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development.},
  author={Barbara Ritter and Jana Zsch{\"u}ntsch and Elena Kvachnina and Weiqi Zhang and Evgeni G. Ponimaskin},
  journal={Brain research. Developmental brain research},
  year={2004},
  volume={149 1},
  pages={73-7}
}
Gamma-aminobutyric acid type B receptors (GABA(B)R) belong to the family of G-protein-coupled receptors that mediate synaptic actions by modulation of different ion channels. Here, we demonstrate that the receptor subunits GABA(B)R1 and GABA(B)R2 interact directly with the soluble activating transcription factor 4 (ATF4) in different regions of the neonatal mouse brain. We found that about 5-12% of expressed ATF4 protein is involved in the complex formation with GABA(B) receptors. Confocal… CONTINUE READING