The GABA(A) receptor antagonist picrotoxin inhibits 5-hydroxytryptamine type 3A receptors.

@article{Das2003TheGR,
  title={The GABA(A) receptor antagonist picrotoxin inhibits 5-hydroxytryptamine type 3A receptors.},
  author={Paromita Das and Cathy L. Bell-Horner and Tina K Machu and Glenn H. Dillon},
  journal={Neuropharmacology},
  year={2003},
  volume={44 4},
  pages={431-8}
}
For a number of years it has been known that the CNS convulsant picrotoxin inhibits the GABA(A) receptor, an anion-selective member of the ligand-gated ion channel (LGIC) superfamily. PTX also inhibits other anion-selective LGIC members, such as GABA(C), glycine and glutamate-gated Cl(-) channels. In the present report, we tested the ability of picrotoxin to inhibit cation-selective 5-HT(3A) receptors. Murine 5-HT(3A) receptors were expressed in HEK293 cells, and functionally evaluated using… CONTINUE READING
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