The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor.

@article{Goldwurm2005TheG,
  title={The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor.},
  author={Stefano Goldwurm and Andrea di Fonzo and Erik J. Simons and Christan F. Roh{\'e} and Matteo Zini and Margherita Canesi and Silvana Tesei and Anna Lena Zecchinelli and Alessandro Antonini and Chiara Mariani and Nicoletta Meucci and Giorgio Sacilotto and Francesca Sironi and Giuliana Salani and Joana Ferreira and Hsin Fen Chien and Edito Fabrizio and Nicola Vanacore and Alessio Dalla Libera and Fabrizio Stocchi and Cosimo Diroma and Paola Lamberti and Cristina Sampaio and Giuseppe Meco and Eudes Barbosa and Aida M. Bertoli-Avella and Guido J. Breedveld and Ben A. Oostra and Gianni Pezzoli and Vincenzo Bonifati},
  journal={Journal of medical genetics},
  year={2005},
  volume={42 11},
  pages={e65}
}
BACKGROUND Mutations in the gene Leucine-Rich Repeat Kinase 2 (LRRK2) were recently identified as the cause of PARK8 linked autosomal dominant Parkinson's disease. OBJECTIVE To study recurrent LRRK2 mutations in a large sample of patients from Italy, including early (<50 years) and late onset familial and sporadic Parkinson's disease. RESULTS Among 629 probands, 13 (2.1%) were heterozygous carriers of the G2019S mutation. The mutation frequency was higher among familial (5.1%, 9/177) than… CONTINUE READING