The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits.

@article{Lee1992TheGM,
  title={The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits.},
  author={Edward Wolfgang Lee and Ronald Taussig and Alfred G. Gilman},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 2},
  pages={1212-8}
}
Adenylylcyclase cannot be activated by hormones or guanine nucleotide analogs in membranes from cells that express the G226A mutant form Gs alpha instead of the wild-type protein. The mutant Gs alpha protein appears incapable of undergoing the conformational change necessary for guanine nucleotide-induced dissociation of the G protein alpha subunit from the beta gamma subunit complex (Miller, R.T., Masters, S.B., Sullivan, K.A., Beiderman, B., and Bourne, H.R. (1988) Nature 334, 712-715). G226A… CONTINUE READING

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