The G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2.

@article{Jamal2015TheGP,
  title={The G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2.},
  author={Azfar Jamal and Manickavinayaham Swarnalatha and Sarwat Sultana and Prashant Joshi and Subrat Kumar Panda and Vijay Kumar},
  journal={Cell cycle},
  year={2015},
  volume={14 16},
  pages={2688-700}
}
E3 ubiquitin ligases have been implicated in the ubiquitination and proteasome-mediated degradation of several key regulators of cell cycle. Owing to their pleotropic behavior, E3 ubiquitin ligases are tightly regulated both at transcriptional and post-translational levels. The E3 ubiquitin ligase TRUSS (tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein) which negatively regulates c-Myc, are found down-regulated in most human cancer cell lines. However, the… CONTINUE READING
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