The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins

@article{Krapivinsky1995TheGA,
  title={The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins},
  author={G. Krapivinsky and E. A. Gordon and K. Wickman and B. Velimirovic and L. Krapivinsky and D. Clapham},
  journal={Nature},
  year={1995},
  volume={374},
  pages={135-141}
}
  • G. Krapivinsky, E. A. Gordon, +3 authors D. Clapham
  • Published 1995
  • Biology, Medicine
  • Nature
  • Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K+) channel, IKACh. Activated muscarinic receptors stimulate lKAch via the G-protein βγ-subunits. It has been assumed that the inwardly rectifying K+-channel gene, GIRK1, alone encodes IKAch-It is now shown that IKAch is a heteromultimer of two distinct inwardly rectifying K+-channel subunits, GIRK1 and a newly cloned member of the family, CIR. 
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