The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.

@article{Fredriksson2003TheGR,
  title={The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.},
  author={Robert Fredriksson and Malin Charlotta Lagerstr{\"o}m and Lars-G. Lundin and Helgi Birgir Schi{\"o}th},
  journal={Molecular pharmacology},
  year={2003},
  volume={63 6},
  pages={
          1256-72
        }
}
The superfamily of G-protein-coupled receptors (GPCRs) is very diverse in structure and function and its members are among the most pursued targets for drug development. We identified more than 800 human GPCR sequences and simultaneously analyzed 342 unique functional nonolfactory human GPCR sequences with phylogenetic analyses. Our results show, with high bootstrap support, five main families, named glutamate, rhodopsin, adhesion, frizzled/taste2, and secretin, forming the GRAFS classification… 
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