The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation.

@article{Veldhuis2015TheGP,
  title={The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation.},
  author={Nicholas A. Veldhuis and Daniel P Poole and Megan S Grace and Peter McIntyre and Nigel W Bunnett},
  journal={Pharmacological reviews},
  year={2015},
  volume={67 1},
  pages={36-73}
}
Sensory nerves are equipped with receptors and ion channels that allow them to detect and respond to diverse chemical, mechanical, and thermal stimuli. These sensory proteins include G protein-coupled receptors (GPCRs) and transient receptor potential (TRP) ion channels. A subclass of peptidergic sensory nerves express GPCRs and TRP channels that detect noxious, irritant, and inflammatory stimuli. Activation of these nerves triggers protective mechanisms that lead to withdrawal from danger… CONTINUE READING