The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells.

@article{Vivacqua2006TheGP,
  title={The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells.},
  author={Adele Vivacqua and Daniela Bonofiglio and Anna Grazia Recchia and Anna Maria Musti and Didier Picard and Sebastiano And{\'o} and Marcello Maggiolini},
  journal={Molecular endocrinology},
  year={2006},
  volume={20 3},
  pages={631-46}
}
The growth of both normal and transformed epithelial cells of the female reproductive system is stimulated by estrogens, mainly through the activation of estrogen receptor alpha (ERalpha), which is a ligand-regulated transcription factor. The selective ER modulator tamoxifen (TAM) has been widely used as an ER antagonist in breast tumor; however, long-term… CONTINUE READING