The G protein-coupled receptor GPR30 mediates the nontranscriptional effect of estrogen on the activation of PI3K/Akt pathway in endometrial cancer cells.

@article{Ge2013TheGP,
  title={The G protein-coupled receptor GPR30 mediates the nontranscriptional effect of estrogen on the activation of PI3K/Akt pathway in endometrial cancer cells.},
  author={Xin Ge and Ruixia Guo and Yu-huan Qiao and Yancai Zhang and Jia Chuan Lei and Xinyan Wang and Liuxia Li and Dongmei Hu},
  journal={International journal of gynecological cancer : official journal of the International Gynecological Cancer Society},
  year={2013},
  volume={23 1},
  pages={52-9}
}
OBJECTIVE The goal of this study was to investigate the effect of G protein-coupled receptor 30 (GPR30) on the activation of PI3K/Akt pathway induced by E2 in endometrial cancer cells. METHODS AND MATERIALS Immunohistochemistry was performed to determine the location and expression of GPR30, estrogen receptors (ERs), Akt, and phosphorylated Akt. We also investigated the expression of GPR30, ERs, and the level of phosphorylation of Akt induced by E2 in endometrial cancer cells, Ishikawa cells… CONTINUE READING
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