The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells.

@article{Maggiolini2004TheGP,
  title={The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells.},
  author={Marcello Maggiolini and Adele Vivacqua and Giuseppe Fasanella and Anna Grazia Recchia and Diego Sisci and Vincenzo Pezzi and Daniela Montanaro and Anna Maria Musti and Didier Picard and Sebastiano And{\'o}},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 26},
  pages={
          27008-16
        }
}
A growing body of evidence concerning estrogen effects cannot be explained by the classic model of hormone action, which involves the binding to estrogen receptors (ERs) alpha and ERbeta and the interaction of the steroid-receptor complex with specific DNA sequences associated with target genes. Using c-fos proto-oncogene expression as an early molecular sensor of estrogen action in ERalpha-positive MCF7 and ER-negative SKBR3 breast cancer cells, we have discovered that 17beta-estradiol (E2… CONTINUE READING
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