The G protein-coupled receptor GPR30 inhibits human urothelial cell proliferation.

@article{Teng2008TheGP,
  title={The G protein-coupled receptor GPR30 inhibits human urothelial cell proliferation.},
  author={Jian Teng and Zun-yi Wang and Eric R Prossnitz and Dale E. Bjorling},
  journal={Endocrinology},
  year={2008},
  volume={149 8},
  pages={4024-34}
}
We have previously shown that estrogen stimulates cell proliferation in both normal and transformed urothelial cells mainly through activation of the two primary estrogen receptors (ERs), ERalpha and ERbeta. A growing body of evidence suggests that estrogen also initiates nongenomic effects that cannot be explained by activation of primary ERs. In the present study, we observed that urothelial cells express high amounts of GPR30, a G protein-coupled receptor recently identified as a candidate… CONTINUE READING

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