The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis

@inproceedings{Jin2017TheGC,
  title={The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis},
  author={Guangchun Jin and Kosuke Sakitani and Hongshan Wang and Ying Jin and Alexander N Dubeykovskiy and Daniel L. Worthley and Yagnesh H Tailor and Timothy C Wang},
  booktitle={Oncotarget},
  year={2017}
}
Overexpression of human progastrin increases colonic mucosal proliferation and colorectal cancer progression in mice. The G-protein coupled receptor 56 (GPR56) is known to regulate cell adhesion, migration, proliferation and stem cell biology, but its expression in the gut has not been studied. We hypothesized that the promotion of colorectal cancer by progastrin may be mediated in part through GPR56. Here, we found that GPR56 expresses in rare colonic crypt cells that lineage trace colonic… CONTINUE READING
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