The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium

  title={The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium},
  author={Li Jie Wu and Roelf Valkema and Peter J M Van Haastert and Peter N. Devreotes},
  journal={The Journal of Cell Biology},
  pages={1667 - 1675}
Increasing evidence suggests that the beta gamma-subunit dimers of heterotrimeric G proteins play a pivotal role in transducing extracellular signals. The recent construction of G beta null mutants (g beta-) in Dictyostelium provides a unique opportunity to study the role of beta gamma dimers in signaling processes mediated by chemoattractant receptors. We have shown previously that g beta- cells fail to aggregate; in this study, we report the detailed characterization of these cells. The g… CONTINUE READING
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