The G protein Gα12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain

@article{Jiang1998TheGP,
  title={The G protein Gα12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain},
  author={Ying Jiang and W. T. Ma and Yong Wan and Tohru Kozasa and Seisuke Hattori and X. X. Huang},
  journal={Nature},
  year={1998},
  volume={395},
  pages={808-813}
}
Heterotrimeric guanine-nucleotide-binding proteins (G proteins) are signal transducers that relay messages from many receptors on the cell surface to modulate various cellular processes. The direct downstream effectors of G proteins consist of the signalling molecules that are activated by their physical interactions with a Gα or Gβγ subunit. Effectors that interact directly with Gα12 G proteins have yet to be identified,. Here we show that Gα12 binds directly to, and stimulates the activity of… CONTINUE READING