The G-protein Coupled Receptor Family : Actors with Many Faces

  title={The G-protein Coupled Receptor Family : Actors with Many Faces},
  author={Liapakis George and Cordom{\'i} Arnau and Pardo Leonardo},
  • Liapakis George, Cordomí Arnau, Pardo Leonardo
  • Published 2011
G-protein coupled receptors (GPCRs) comprise the largest family of proteins in our body, which have many important physiological functions and are implicated in the pathophysiology of many serious diseases. GPCRs therefore are significant targets in pharmaceutical research. GPCRs share the common architecture of seven plasma membrane-spanning segments connected to each other with three extracellular and three intracellular loops. In addition, GPCRs contain an extracellular N-terminal region and… CONTINUE READING