The G-protein–gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation

@inproceedings{Mesirca2013TheGK,
  title={The G-protein–gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation},
  author={Pietro Mesirca and Laurine Marger and Futoshi Toyoda and Riccardo Rizzetto and Matthieu Audoubert and Stefan J. Dubel and Angelo Giovanni Torrente and Mattia Lorenzo DiFrancesco and Jana Christina Muller and Antonio Leoni and Brigitte Couette and Jo{\"e}l Nargeot and David E Clapham and Kevin Wickman and Matteo E Mangoni},
  booktitle={The Journal of general physiology},
  year={2013}
}
Parasympathetic regulation of sinoatrial node (SAN) pacemaker activity modulates multiple ion channels to temper heart rate. The functional role of the G-protein-activated K(+) current (IKACh) in the control of SAN pacemaking and heart rate is not completely understood. We have investigated the functional consequences of loss of IKACh in cholinergic regulation of pacemaker activity of SAN cells and in heart rate control under physiological situations mimicking the fight or flight response. We… CONTINUE READING

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