The G‐protein coupling properties of the human sweet and amino acid taste receptors

@article{Sainz2007TheGC,
  title={The G‐protein coupling properties of the human sweet and amino acid taste receptors},
  author={Eduardo Sainz and Margaret M. Cavenagh and Nelson D Lopezjimenez and Joanne Gutierrez and James F. Battey and John K. Northup and Susan L. Sullivan},
  journal={Developmental Neurobiology},
  year={2007},
  volume={67}
}
The human T1R taste receptors are family C G‐protein‐coupled receptors (GPCRs) that act as heterodimers to mediate sweet (hT1R2 + hT1R3) and umami (hT1R1 + hT1R3) taste modalities. Each T1R has a large extracellular ligand‐binding domain linked to a seven transmembrane‐spanning core domain (7TMD). We demonstrate that the 7TMDs of hT1R1 and hT1R2 display robust ligand‐independent constitutive activity, efficiently catalyzing the exchange of GDP for GTP on Gα subunits. In contrast, relative to… 
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Umami taste transduction mechanisms 1 – 4
L-Glutamate elicits the umami taste sensation, now recognized as a fifth distinct taste quality. A characteristic feature of umami taste is its potentiation by 5#-ribonucleotides such as
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TLDR
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Umami taste transduction mechanisms.
  • S. Kinnamon
  • Biology
    The American journal of clinical nutrition
  • 2009
l-Glutamate elicits the umami taste sensation, now recognized as a fifth distinct taste quality. A characteristic feature of umami taste is its potentiation by 5'-ribonucleotides such as
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