The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians.

@article{Carrieri2004TheGP,
  title={The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians.},
  author={Giuseppina Carrieri and Erika Marzi and Fabiola Olivieri and Francesca Marchegiani and Luca Cavallone and Maurizio Cardelli and Simona Giovagnetti and Rosalia Stecconi and Cinzia Molendini and Chiara Trapassi and Giovanna de Benedictis and Dimitri Kletsas and Claudio Franceschi},
  journal={Aging cell},
  year={2004},
  volume={3 6},
  pages={443-8}
}
Sequence variations in a variety of pro- or anti-inflammatory cytokine genes have been found to influence successful aging and longevity. Because of the role played by the transforming growth factor beta1 (TGF-beta1) cytokine in inflammation and regulation of immune responses, the variability of the TGF-beta1 gene may affect longevity by playing a role in inflamm-aging. Two polymorphisms, G/A -800 and C/T -509, located in the 5' region, and two missense polymorphisms, T/C 869 and G/C 915 which… CONTINUE READING
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